| Field Name |
Data Description |
| Test Name |
Diazepam Level |
| Code |
Diazepam Level. |
|
CPT Code |
80346 |
| Last Modified |
3/21/2018 2:56:00 PM |
| Test Name |
Dizepam. |
| Synonyms |
Diastat, Diazemuls, Dizac, Diastat Acudial, Intensol, Valium, nordiazepam |
| Patient Preparation |
|
| Spec. Requirements |
Blood |
| Tube |
Red, Lavender(EDTA), or Drk Green(Li or Na heparin) |
| Collection Volume |
4.0 mL Red, 4.0 mL Drk Green, or 2.0 mL Lavender |
| Storage |
Refrigerate |
| Routine TAT |
2-5 days |
| STAT TAT |
N/A |
| Days Test Performed |
Monday - Friday |
| Performed by BHS |
None |
| See Availability |
|
| Reference Lab |
LabCorp of America |
| Reference Lab Code |
007989 Diazepam |
| Clinical Use |
Diazepam is effective in the management of generalized anxiety disorder and panic disorder in appropriately selected patients. Its use prior to endoscopy or cardioversion relieves anxiety and diminishes the patient's recall of the procedure. Preoperative use relieves anxiety and tension and may provide anterograde amnesia. Additional uses include the treatment of skeletal muscle spasms due to inflammation or trauma, spasticity (eg, multiple sclerosis, cerebral palsy, paraplegia, stiff-man syndrome), seizure disorders (eg, status epilepticus, febrile seizures), and alleviation of abstinence symptoms during alcohol withdrawal. Diazepam is a muscle relaxant and antianxiety drug. Peak blood levels are achieved within an hour after oral dose. Half-life in adults is 21 to 37 hours. The major metabolite (nordiazepam) has a half-life in adults of 50 to 99 hours. It is the major metabolite also of clorazepate and prazepam. Minor active metabolites of diazepam are temazepam (3-hydroxydiazepam) and oxazepam (3-hydroxy-N-diazepam). |
| Reference Range |
|
| Critical Value |
|
|
Component |
|
|
Reference Range |
|
|
Critical Value |
|
 |
|
Component |
Nordiazepam |
|
Reference Range |
|
|
Critical Value |
|
|
|
Component |
Diazepam + Nordiazepam |
|
Reference Range |
|
|
Critical Value |
|
|
|
| Testing Sample Type |
Serum or Plasma |
| Min Lab Testing Volume |
0.8 mL |
| Special Handling |
Collection Transfer separated serum or plasma to a plastic transport tube. Oral: peak: one hour after dose; IV: peak: 15 minutes after dose. |
| Lab Notes |
|
| Methodology |
Liquid Chromatography/Tamdem Mass Spectrophotometry (LC/MS/MS) |
| Limitations |
Rejection: Gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
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