| Field Name |
Data Description |
| Test Name |
Everolimus |
| Code |
Everolimus. |
|
CPT Code |
80169 |
| Last Modified |
|
| Test Name |
Everolimus. |
| Synonyms |
Afinit |
| Patient Preparation |
|
| Spec. Requirements |
Whole Blood |
| Tube |
Lavender (EDTA) or Dark Green (Heparin) |
| Collection Volume |
2.0 mL Lavender or 4.0 mL Green |
| Storage |
Ambient, Refrigerate or Frozen 14 days |
| Routine TAT |
|
| STAT TAT |
N/A |
| Days Test Performed |
|
| Performed by BHS |
None |
| See Availability |
|
| Reference Lab |
LabCorp of America |
| Reference Lab Code |
700003 Everolimus, Whole Blood |
| Clinical Use |
Everolimus is a proliferation signal inhibitor that prevents allograft rejection. It exerts its immunosuppressive effect by inhibiting the proliferation, and thus clonal expansion, of antigen-activated T cells, which is driven by T-cell-specific interleukins. Everolimus inhibits an intracellular signaling pathway that is triggered up binding of these T-cell growth factors to their respective receptors, and which normally leads to cell proliferation. The blockage of this signal by everolimus leads to an arrest of the cells at the G1 stage of cell cycle. |
| Reference Range |
|
| Critical Value |
|
|
|
| Testing Sample Type |
Whole blood |
| Min Lab Testing Volume |
0.5 mL |
| Special Handling |
|
| Lab Notes |
|
| Methodology |
LC/MS-MS - Liquid Chromatography/Tandem Mass Spectrometry |
| Limitations |
|
