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 Field Name  Data Description
Test Name  Lipoprotein A
Code  Lipoprotein a., Lipo a.
CPT Code  83695
Last Modified  4/24/2018 12:59:00 PM
Test Name  Lipopro A.
Synonyms  LPA, Lipopr, LP A, LP, Quantitation of Lpa
Patient Preparation  Intake of alcohol, aspirin, niacin, and estrogen supplementshave the potential of causing a misrepresentation of true Lp(a) concentrations.
Spec. Requirements  Blood
Tube  Red, Gold, Green (Heparin), Lavender (EDTA), or Blue-top (Citrate) tube
Collection Volume  Red 4.0 mL, Gold 3.5 mL, Green (Heparin) 3.5 or 4.0 mL, Lavender (EDTA) 2.0 mL, Blue (Citrate) 2.7 mL
Storage  Refrigerated 14 days or Frozen >14 days
Routine TAT  
Days Test Performed  
Performed by BHS  None
See Availability  
Reference Lab  LabCorp of America
Reference Lab Code  120188 Lipoprotein (a)
Clinical Use  Lp(a) determination is intended for use in conjunction with clinical evaluation, patient risk assessment, and other lipid tests to evaluate disorders of lipid metabolism and toassess coronary heart disease in specific populations. Measurement of lipoprotein(a) is now recommended in several patient subgroups for whom excess lipoprotein(a) may have important clinical consequences: (1) patients with premature atherosclerosis, (2) patients with a strong familyhistory of premature coronary heart disease (CHD), (3) patients with elevated LDL-C and greater than or equal to two risk factors, (4) patients who have had coronary angioplasty in whom lipoprotein(a) excess may increase the risk of restenosis, and (5) patients who have undergone coronary bypass graft surgery in whom Lp(a) excess may be associated with graft stenosis.[1,2] Lipoprotein(a) has been called a powerful predictor of premature atherosclerotic vascular disease.[1] As an independent risk factor for premature coronary artery disease, excess Lp(a) concentrations are associated with an increased risk of cardiac death in patients with acute coronary syndromes and with restenosis after angioplasty (PTCA) and coronary bypass procedures. In general, concentrations greater than or equal to 75 nmol/L of Lp(a) in serum are associated with a two- to sixfold increase in risk, depending on the presence of other risk factors.
Reference Range  
Critical Value  
Testing Sample Type  Serum (Preferred) or Plasma
Min Lab Testing Volume  0.2 mL
Special Handling  Separate serum or plasma from cells as soon as possible (within two hours).
Lab Notes  Causes for rejection: Grossly hemolyzed, lipemic or icteric specimens
Methodology  IT - Immunoturbidimetric
Limitations  Lp(a) is an independent risk factor for coronary artery disease and cerebral infarction (in white populations) equal to high LDL cholesterol. Serum concentrations are genetically determined. Fifteen percent to 20% of the white population have Lp(a) levels greater than or equal to 75 nmol/L and are presumed to be at risk. Race-dependent differences in Lp(a) concentrations are known. Significance of high Lp(a) in nonwhite populations must be evaluated withcaution. The Lp(a) levels in different ethnic populations can vary widely. Africans, or people of African descent, generally have Lp(a) levels higher than Caucasians and Asians, while Native Americans generally have levels lower than Caucasians. This variability of Lp(a) levels by ethnic population requires careful interpretation of results based on a knowledge of the patient and other cardiac risk factorsthat may be present.[3]

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