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 Field Name  Data Description
Test Name  Neuron Specific Enolase.
Code  Neuron Specific Enolase.
CPT Code  86316
Last Modified  4/26/2018 11:47:00 AM
Test Name  NSE.
Synonyms  Tumor, NSE, Enolas, Specif, Neurol, Neuron, Nsenol,
Patient Preparation  
Spec. Requirements  CSF
Tube  Red or Gold
Collection Volume  Red 4.0 mL or Gold 3.5 mL
Storage  Refrigeration ONLY
Routine TAT  
Days Test Performed  
Performed by BHS  None
See Availability  
Reference Lab  LabCorp of America
Reference Lab Code  140624 Neuron-specific Enolase, Serum
Clinical Use  NSE is a useful adjunct in the monitoring of patients with small cell lung cancer (SCLC). Neuron specific enolase is one of the five isozymes of the glycolytic enzyme, enolase. This enzyme is released into the CSF when neural tissue is injured. Neoplasms derived from neural or neuroendocrine tissue may release NSE into the blood. The test may have value in predicting response to therapy. In a group of 13 patients with small cell carcinoma of lung, very high levels of NSE (greater than or equal to 100 ng/mL, mean of 490 ng/mL) were found in seven of eight responders. Levels <100 ng/mL (mean 28 ng/mL) were found in the remaining six patients, only two of whom were responders. These values are from samples obtained during the first three-day course of chemotherapy. There is evidence that the level of serum neuron-specific enolase correlates with tumor burden.[1-3] Increase occurs more commonly and is at higher levels in advanced stage than in limited stage disease.[3] The enzyme has been elevated in sera of all patients with three or more sites of metastases.[1] Serum NSE levels are increased in cases of neuroblastoma,[4] but also in other tumors.[5] Levels >100 ng/mL in children are, however, highly suggestive of advanced neuroblastoma. Use of NSE to monitor treated neuroblastoma patients has not been found to be a sensitive index of residual tumor.[5] NSE levels may also be increased in some patients with seminoma[6] and some patients with uremia who have been on dialysis.[7]
Reference Range  
Critical Value  
Testing Sample Type  Serum
Min Lab Testing Volume  0.3 mL
Special Handling  Values obtained with different assay methods should not be used interchangeably in serial testing. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. This procedure does not provide serial monitoring; it is intended for one-time use only. If serial monitoring is required, please use the serial monitoring number (480137) to order.
Lab Notes  Collection: Transfer separated serum to a plastic transport tube as quickly as possible after the clot has formed (within 30 minutes of collection). Causes for rejection: Hemolysis; plasma specimen; recently administered isotopes
Methodology  Enzyme Immunoassay (EIA)
Limitations  NSE is not a screening test. Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

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